Louisville Cardinals vs Duke Blue Devils Pick & Prediction - 1/26/2026
Updated January 26, 2026
Updated January 26, 2026
Duke returns to Cameron Indoor Stadium for a big Monday rematch with Louisville. Cameron Boozer has looked every bit like a Wooden front-runner for Duke, while Louisville has its top star with Mikel Brown Jr. returning to action over the weekend. With Duke unbeaten at home and Louisville looking to flip the script after leading at halftime but fading late in their first meeting, you can find my Louisville vs Duke prediction below.
Pick: Duke -7.5 ATS PRO
Confidence: 3/5
Score Projection: Louisville 74 – Duke 84
Win Probability: Louisville 31%, Duke 69%
Duke should have the upper hand against Louisville once again on Monday night. The Blue Devils have a true game-breaker in Boozer who should be able to help his team generate offense no matter what Louisville's defense throws at them. Expect Duke to win by double-digits again and for the Blue Devils to cover the spread when all is said and done in this marquee matchup.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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